Particle Detector - List of Manufacturers, Suppliers, Companies and Products

Introduction of HPLC-CAD case studies that address HPLC-UV concerns.

A universal detector that measures various analytical substances with consistent responsiveness.

A universal charged aerosol detector (CAD) that measures various analytical target substances with consistent responsiveness can provide consistent area response on chromatograms regardless of the chemical structure of non-volatile analytes, ranging from ions to proteins. Additionally, its wide dynamic range allows for high-sensitivity detection. HPLC-CAD is utilized for the detection and quantification of compounds that are difficult to measure with UV detectors in various fields such as food, pharmaceuticals, and materials science. Please refer to the PDF for practical examples.

Company：サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K.
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Vanquish Charged Particle Detector (CAD)

Active in the chemical industry! Avoid missing non-volatile compounds.

This product is a universal charged particle detector that measures various analytes with consistent responsiveness. Its wide dynamic range allows for high-sensitivity detection. It is utilized for the detection and quantification of compounds that are difficult to measure with UV detectors in various fields such as food, pharmaceuticals, and materials science. 【Features】 - Simple and intuitive operability - Compatible with UHPLC/HPLC - Easy switching function for parallel detection (such as MS) - Allows changing the mobile phase from volatile to non-volatile without removing the detector from the system - Wide flow range (0.01 to 2.0 ml/min) *For more details, please refer to the PDF document or feel free to contact us.

Company：サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K.
Price：Other

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[Case Study] Advantages of Charged Particle Detectors in SEC Analysis

HPLC method achieving high-sensitivity quantitative analysis without complex preprocessing: Introducing quantitative know-how for quality control.

This application note introduces the analysis of polymer compounds using size exclusion chromatography (SEC) with the Vanquish Charged-Aerosol Detector (CAD). The CAD has approximately 100 times the sensitivity compared to a differential refractive index detector (RI) and is a versatile detector capable of accurately detecting semi-volatile and non-volatile components. Its wide dynamic range and excellent stability make it ideal for analyzing molecular weight distributions. This document discusses the detection of calibration standard samples and calibration curves, comparisons of sensitivity, and changes in retention time due to sample concentration, using polystyrene samples to compare RI and explain the characteristics and advantages of CAD. 【Features】 ■ High sensitivity detection: CAD achieves approximately 100 times the sensitivity compared to RI ■ Wide dynamic range: Accurately measures samples of diverse molecular weights ■ Detection in the polymer range: Effectively detects polymers with molecular weights up to 400,000 ■ Low concentration measurement: Minimal concerns about carryover or column loading even at low concentrations ■ Stability: Provides rapid stabilization and consistent results

Company：サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K.
Price：Other

Analytical Equipment and Devices

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Features and Principles of the Corona Charged Particle Detector (CAD)

Here is an example comparing the analysis results of catechin standard solutions using CAD and UV detectors.

The Corona Charged Aerosol Detector (CAD) detects components after they have been separated by HPLC and nebulized, followed by solvent removal. Therefore, volatile substances cannot be detected, but everything else is subject to detection. In CAD, particles are given a charge, and by measuring the amount of that charge, an area value corresponding to the amount of the component is obtained. In the case of a UV detector, the area value can vary significantly depending on the component, even at the same concentration, but in CAD, the difference in area values is about 10%. 1. Non-volatile and semi-volatile substances can be detected even if they do not have UV absorption. 2. Consistent responsiveness is obtained depending on the weight of the substance, allowing for semi-quantitative analysis even without standard samples. 3. High sensitivity detection is possible regardless of chemical structure (detection limits are around several hundred pg to several ng). 4. Gradient analysis is possible.